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Bruce O'Hara

Research Interests:
Sleep and Circadian Rhythms
Education

Ph.D. The Johns Hopkins Univ., 1988

Research

Sleep and Circadian Rhythms

 

My research addresses questions related to sleep and circadian rhythms.  The research ranges from molecular and genetic approaches to behavioral studies in mice and humans.  Great progress has been made recently in understanding fundamental aspects of circadian rhythms, but many aspects of sleep are poorly understood.  Although sleep occupies approximately one third of our lives, we still cannot answer the basic question of why we sleep.  It now appears that most animals have some form of sleep, and birds and mammals generally have two very different kinds of sleep – Rapid-Eye-Movement (REM) sleep and non-REM sleep that may serve different or complementary functions.  In addition to fundamental questions about sleep function and sleep regulation, sleep is also of great medical and societal importance.  Sleep disturbances afflict approximately 75 million people in the United States alone, and even normal sleepers often get insufficient sleep due to lifestyle factors that can result in serious accidents, poor performance, lowered quality of life, and even grouchiness.  Clearly, something about the brain requires sleep and, in our view, genetic approaches in mice provide one of the best opportunities for a better understanding of sleep.   

Mice are an excellent model organism for genetic studies because there is a wide diversity of inbred strains.  Members of each individual inbred strain are genetically identical, like identical twins in humans, but among different strains there are many different alleles of each gene that contribute to physiological and behavioral differences.  We are currently investigating differences in sleep traits and other variables in diverse sets and combinations of inbred strains, and in genetically altered mice such as single gene knockouts.   

A major limitation in all studies of sleep in mice, or any mammal, is the difficulty of performing EEG/EMG analyses.  In mice and other rodents, this requires extensive surgery, recovery, cabling of animals, and considerable time for signal analyses.   Therefore, we developed a non-invasive, high-throughput alternative using a piezoelectric film attached to the floor of a mouse or rat cage, and then developed signal processing algorithms to score sleep and wake in real time.  This work is being done in collaboration with Prof. Kevin Donohue in Engineering and a team of researchers at a company we founded called Signal Solutions.  We currently have our system in use throughout the world, including many that we also collaborate with in areas such as Alzheimer's Disease, Traumatic Brain Injury, Epilepsy, COVID and infectious diseases, Opioid overdose, and many more.  Our system is also used at major interational centers performing large scale genomic screens to find genes and gene alleles that influence sleep, wake, activity, breathing, and many other behaviors, including several collaborations with investigators at The Jackson Laboratory.    

In addition to our studies in mice, we are also studying various aspects of sleep, meditation and performance in people, such as whether meditation might provide some of the restoration we normally associate with sleep.  We are using a well-validated psychomotor vigilance test that accurately reflects underlying sleepiness.  Our data thus far suggest meditation can indeed boost performance, and in a way that appears to compensate or pay-off sleep debt at least to a modest degree.   

 

 

Selected Publications:

Kaul P, J Passafiume, RC Sargent, BF O’Hara.  Meditation acutely improves psychomotor vigilance and may decrease sleep need.  Behav Brain Functions.  6:47 (pp. 1-9)  (2010).  

PubMed Publications*: 
  • MJ Duncan; LE Guerriero; K Köhler; LE Beechem; BD Gillis; F Salisbury; C Wessel; J Wang; S Sunderam; AD Bachstetter; BF O'Hara; MP Murphy"Chronic Fragmentation of the Daily Sleep-Wake Rhythm Increases Amyloid-beta Levels and Neuroinflammation in the 3xTg-AD Mouse Model of Alzheimer's Disease."Neuroscience481.(2022):111-122.Details. Full text
  • PJ Lituma; E Woo; BF O'Hara; PE Castillo; NES Sibinga; S Nandi"Altered synaptic connectivity and brain function in mice lacking microglial adapter protein Iba1."Proceedings of the National Academy of Sciences of the United States of America118.46(2021):Details. Full text
  • KL Proudfoot; JA Kull; PD Krawczel; JM Bewley; BF O'Hara; KD Donohue; GM Pighetti"Effects of acute lying and sleep deprivation on metabolic and inflammatory responses of lactating dairy cows."Journal of dairy science104.4(2021):4764-4774.Details. Full text
  • D Huffman; A Ajwad; F Yaghouby; BF O'Hara; S Sunderam"A real-time sleep scoring framework for closed-loop sleep manipulation in mice."Journal of sleep research30.4(2021):e13262.Details. Full text
  • JA Bubier; VM Philip; C Quince; J Campbell; Y Zhou; T Vishnivetskaya; S Duvvuru; RH Blair; J Ndukum; KD Donohue; CM Foster; DJ Mellert; G Weinstock; CT Culiat; BF O'Hara; AV Palumbo; M Podar; EJ Chesler"A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice."Genetics214.3(2020):719-733.Details. Full text
  • I Mishra; KB Pullum; DC Thayer; ER Plummer; BW Conkright; AJ Morris; BF O'Hara; GE Demas; NT Ashley"Chemical sympathectomy reduces peripheral inflammatory responses to acute and chronic sleep fragmentation."American journal of physiology. Regulatory, integrative and comparative physiology318.4(2020):R781-R789.Details. Full text
  • C Wang; LE Guerriero; DM Huffman; AA Ajwad; TC Brooks; S Sunderam; AW Seifert; BF O'Hara"A comparative study of sleep and diurnal patterns in house mouse (Mus musculus) and Spiny mouse (Acomys cahirinus)."Scientific reports10.1(2020):10944.Details. Full text
  • JA Bubier; H He; VM Philip; T Roy; CM Hernandez; R Bernat; KD Donohue; BF O'Hara; EJ Chesler"Genetic variation regulates opioid-induced respiratory depression in mice."Scientific reports10.1(2020):14970.Details. Full text
  • JA Bubier; VM Philip; C Quince; J Campbell; Y Zhou; T Vishnivetskaya; S Duvvuru; RH Blair; J Ndukum; KD Donohue; CM Foster; DJ Mellert; G Weinstock; CT Culiat; BF O'Hara; AV Palumbo; M Podar; EJ Chesler"A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice."Genetics214.3(2020):719-733.Details. Full text
  • RK Rowe; JL Harrison; H Zhang; AD Bachstetter; DP Hesson; BF O'Hara; MI Greene; J Lifshitz"Novel TNF receptor-1 inhibitors identified as potential therapeutic candidates for traumatic brain injury."Journal of neuroinflammation15.1(2018):154.Details. Full text
  • AL Robinson-Junker; BF O'Hara; BN Gaskill"Out Like a Light? The Effects of a Diurnal Husbandry Schedule on Mouse Sleep and Behavior."Journal of the American Association for Laboratory Animal Science : JAALAS57.2(2018):124-133.Details. Full text
  • F Yaghouby; KD Donohue; BF O'Hara; S Sunderam"Noninvasive dissection of mouse sleep using a piezoelectric motion sensor."Journal of neuroscience methods259.(2016):90-100.Details. Full text
  • F Yaghouby; BF O'Hara; S Sunderam"Unsupervised Estimation of Mouse Sleep Scores and Dynamics Using a Graphical Model of Electrophysiological Measurements."International journal of neural systems26.4(2016):1650017.Details. Full text
  • DM Huffman; KE Staggs; F Yaghouby; A Agarwal; BF O'Hara; KD Donohue; EM Blalock; S Sunderam"Tunable somatosensory stimulation for selective sleep restriction studies in rodents."Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference2016.(2016):1640-1643.Details.
  • DM Huffman; KE Staggs; F Yaghouby; A Agarwal; BF O'Hara; KD Donohue; EM Blalock; S Sunderam; DM Huffman; KE Staggs; F Yaghouby; A Agarwal; BF O'Hara; KD Donohue; EM Blalock; S Sunderam; EM Blalock; BF O'Hara; KD Donohue; KE Staggs; S Sunderam; A Agarwal; DM Huffman; F Yaghouby"Tunable somatosensory stimulation for selective sleep restriction studies in rodents."Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference2016.(2016):1640-1643.Details. Full text
  • JM Klefot; JL Murphy; KD Donohue; BF O'Hara; ME Lhamon; JM Bewley"Development of a noninvasive system for monitoring dairy cattle sleep."Journal of dairy science99.10(2016):8477-8485.Details. Full text
  • JL Harrison; RK Rowe; TW Ellis; NS Yee; BF O'Hara; PD Adelson; J Lifshitz"Resolvins AT-D1 and E1 differentially impact functional outcome, post-traumatic sleep, and microglial activation following diffuse brain injury in the mouse."Brain, behavior, and immunity47.(2015):131-40.Details. Full text
  • RK Rowe; JL Harrison; BF O'Hara; J Lifshitz"Recovery of neurological function despite immediate sleep disruption following diffuse brain injury in the mouse: clinical relevance to medically untreated concussion."Sleep37.4(2014):743-52.Details. Full text
  • GM Mang; J Nicod; Y Emmenegger; KD Donohue; BF O'Hara; P Franken"Evaluation of a piezoelectric system as an alternative to electroencephalogram/ electromyogram recordings in mouse sleep studies."Sleep37.8(2014):1383-92.Details. Full text
  • JL Harrison; RK Rowe; BF O'Hara; PD Adelson; J Lifshitz"Acute over-the-counter pharmacological intervention does not adversely affect behavioral outcome following diffuse traumatic brain injury in the mouse."Experimental brain research232.9(2014):2709-19.Details. Full text
  • M Striz; BF O'Hara"Clock genes and sleep homeostasis: a fundamental link within the two-process model?"Sleep36.3(2013):301-2.Details. Full text
  • MJ Duncan; JT Smith; KM Franklin; TL Beckett; MP Murphy; DK St Clair; KD Donohue; M Striz; BF O'Hara"Effects of aging and genotype on circadian rhythms, sleep, and clock gene expression in APPxPS1 knock-in mice, a model for Alzheimer's disease."Experimental neurology236.2(2012):249-58.Details. Full text
  • P Jiang; KM Franklin; MJ Duncan; BF O'Hara; JP Wisor"Distinct phase relationships between suprachiasmatic molecular rhythms, cerebral cortex molecular rhythms, and behavioral rhythms in early runner (CAST/EiJ) and nocturnal (C57BL/6J) mice."Sleep35.10(2012):1385-94.Details. Full text
  • P Jiang; M Striz; JP Wisor; BF O'Hara"Behavioral and genetic dissection of a mouse model for advanced sleep phase syndrome."Sleep34.1(2011):39-48.Details. Full text
  • VM Philip; G Sokoloff; CL Ackert-Bicknell; M Striz; L Branstetter; MA Beckmann; JS Spence; BL Jackson; LD Galloway; P Barker; AM Wymore; PR Hunsicker; DC Durtschi; GS Shaw; S Shinpock; KF Manly; DR Miller; KD Donohue; CT Culiat; GA Churchill; WR Lariviere; AA Palmer; BF O'Hara; BH Voy; EJ Chesler"Genetic analysis in the Collaborative Cross breeding population."Genome research21.8(2011):1223-38.Details. Full text
  • P Kaul; J Passafiume; CR Sargent; BF O'Hara"Meditation acutely improves psychomotor vigilance, and may decrease sleep need."Behavioral and brain functions : BBF6.(2010):47.Details. Full text
  • JP Wisor; P Jiang; M Striz; BF O'Hara"Effects of ramelteon and triazolam in a mouse genetic model of early morning awakenings."Brain research1296.(2009):46-55.Details. Full text
  • KD Donohue; DC Medonza; ER Crane; BF O'Hara"Assessment of a non-invasive high-throughput classifier for behaviours associated with sleep and wake in mice."Biomedical engineering online7.(2008):14.Details. Full text
  • P Franken; R Thomason; HC Heller; BF O'Hara"A non-circadian role for clock-genes in sleep homeostasis: a strain comparison."BMC neuroscience8.(2007):87.Details. Full text
  • AE Flores; JE Flores; H Deshpande; JA Picazo; XS Xie; P Franken; HC Heller; DA Grahn; BF O'Hara"Pattern recognition of sleep in rodents using piezoelectric signals generated by gross body movements."IEEE transactions on bio-medical engineering54.2(2007):225-33.Details. Full text
  • JP Wisor; M Striz; J DeVoss; Murphy GM Jr; DM Edgar; BF O'Hara"A novel quantitative trait locus on mouse chromosome 18, "era1," modifies the entrainment of circadian rhythms."Sleep30.10(2007):1255-63.Details. Full text
  • S Maret; S Dorsaz; L Gurcel; S Pradervand; B Petit; C Pfister; O Hagenbuchle; BF O'Hara; P Franken; M Tafti"Homer1a is a core brain molecular correlate of sleep loss."Proceedings of the National Academy of Sciences of the United States of America104.50(2007):20090-5.Details. Full text
  • BF O'Hara; J Ding; RL Bernat; P Franken"Genomic and proteomic approaches towards an understanding of sleep."CNS & neurological disorders drug targets6.1(2007):71-81.Details.
  • P Franken; CA Dudley; SJ Estill; M Barakat; R Thomason; BF O'Hara; SL McKnight"NPAS2 as a transcriptional regulator of non-rapid eye movement sleep: genotype and sex interactions."Proceedings of the National Academy of Sciences of the United States of America103.18(2006):7118-23.Details. Full text
  • X Xie; T Dumas; L Tang; T Brennan; T Reeder; W Thomas; RD Klein; J Flores; BF O'Hara; HC Heller; P Franken"Lack of the alanine-serine-cysteine transporter 1 causes tremors, seizures, and early postnatal death in mice."Brain research1052.2(2005):212-21.Details. Full text
  • MT Barakat; BF O'Hara; VH Cao; HC Heller; NF Ruby"Light induces c-fos and per1 expression in the suprachiasmatic nucleus of arrhythmic hamsters."American journal of physiology. Regulatory, integrative and comparative physiology289.5(2005):R1381-6.Details. Full text
  • GA Churchill; DC Airey; H Allayee; JM Angel; AD Attie; J Beatty; WD Beavis; JK Belknap; B Bennett; W Berrettini; A Bleich; M Bogue; KW Broman; KJ Buck; E Buckler; M Burmeister; EJ Chesler; JM Cheverud; S Clapcote; MN Cook; RD Cox; JC Crabbe; WE Crusio; A Darvasi; CF Deschepper; RW Doerge; CR Farber; J Forejt; D Gaile; SJ Garlow; H Geiger; H Gershenfeld; T Gordon; J Gu; W Gu; G de Haan; NL Hayes; C Heller; H Himmelbauer; R Hitzemann; K Hunter; HC Hsu; FA Iraqi; B Ivandic; HJ Jacob; RC Jansen; KJ Jepsen; DK Johnson; TE Johnson; G Kempermann; C Kendziorski; M Kotb; RF Kooy; B Llamas; F Lammert; JM Lassalle; PR Lowenstein; L Lu; A Lusis; KF Manly; R Marcucio; D Matthews; JF Medrano; DR Miller; G Mittleman; BA Mock; JS Mogil; X Montagutelli; G Morahan; DG Morris; R Mott; JH Nadeau; H Nagase; RS Nowakowski; BF O'Hara; AV Osadchuk; GP Page; B Paigen; K Paigen; AA Palmer; HJ Pan; L Peltonen-Palotie; J Peirce; D Pomp; M Pravenec; DR Prows; Z Qi; RH Reeves; J Roder; GD Rosen; EE Schadt; LC Schalkwyk; Z Seltzer; K Shimomura; S Shou; MJ Sillanpää; LD Siracusa; HW Snoeck; JL Spearow; K Svenson; LM Tarantino; D Threadgill; LA Toth; W Valdar; FP de Villena; C Warden; S Whatley; RW Williams; T Wiltshire; N Yi; D Zhang; M Zhang; F Zou; Consortium. Trait"The Collaborative Cross, a community resource for the genetic analysis of complex traits."Nature genetics36.11(2004):1133-7.Details. Full text
  • MT Barakat; BF O'Hara; VH Cao; JE Larkin; HC Heller; NF Ruby"Light pulses do not induce c-fos or per1 in the SCN of hamsters that fail to reentrain to the photocycle."Journal of biological rhythms19.4(2004):287-97.Details. Full text
  • IS Hairston; C Peyron; DP Denning; NF Ruby; J Flores; RM Sapolsky; HC Heller; BF O'Hara"Sleep deprivation effects on growth factor expression in neonatal rats: a potential role for BDNF in the mediation of delta power."Journal of neurophysiology91.4(2004):1586-95.Details. Full text
  • O Abiola; JM Angel; P Avner; AA Bachmanov; JK Belknap; B Bennett; EP Blankenhorn; DA Blizard; Bolivar V; GA Brockmann; KJ Buck; JF Bureau; WL Casley; EJ Chesler; JM Cheverud; GA Churchill; M Cook; JC Crabbe; WE Crusio; A Darvasi; G de Haan; P Dermant; RW Doerge; RW Elliot; CR Farber; L Flaherty; J Flint; H Gershenfeld; JP Gibson; J Gu; W Gu; H Himmelbauer; R Hitzemann; HC Hsu; K Hunter; FF Iraqi; RC Jansen; TE Johnson; BC Jones; G Kempermann; F Lammert; L Lu; KF Manly; DB Matthews; JF Medrano; M Mehrabian; G Mittlemann; BA Mock; JS Mogil; X Montagutelli; G Morahan; JD Mountz; H Nagase; RS Nowakowski; BF O'Hara; AV Osadchuk; B Paigen; AA Palmer; JL Peirce; D Pomp; M Rosemann; GD Rosen; LC Schalkwyk; Z Seltzer; S Settle; K Shimomura; S Shou; JM Sikela; LD Siracusa; JL Spearow; C Teuscher; DW Threadgill; LA Toth; AA Toye; C Vadasz; G Van Zant; E Wakeland; RW Williams; HG Zhang; F Zou; Consortium. Trait"The nature and identification of quantitative trait loci: a community's view."Nature reviews. Genetics4.11(2003):911-6.Details. Full text
  • NF Ruby; TJ Brennan; X Xie; Cao V; P Franken; HC Heller; BF O'Hara"Role of melanopsin in circadian responses to light."Science (New York, N.Y.)298.5601(2002):2211-3.Details. Full text
  • JP Wisor; BF O'Hara; A Terao; CP Selby; TS Kilduff; A Sancar; DM Edgar; P Franken"A role for cryptochromes in sleep regulation."BMC neuroscience3.(2002):20.Details. Full text
  • AB Belousov; BF O'Hara; JV Denisova"Acetylcholine becomes the major excitatory neurotransmitter in the hypothalamus in vitro in the absence of glutamate excitation."The Journal of neuroscience : the official journal of the Society for Neuroscience21.6(2001):2015-27.Details. Full text
  • L Bitting; FL Watson; BF O'Hara; TS Kilduff; HC Heller"HSP70 expression is increased during the day in a diurnal animal, the golden-mantled ground squirrel Spermophilus lateralis."Molecular and cellular biochemistry199.1-2(1999):25-34.Details.
  • BF O'Hara; FL Watson; HK Srere; H Kumar; SW Wiler; SK Welch; L Bitting; HC Heller; TS Kilduff"Gene expression in the brain across the hibernation cycle."The Journal of neuroscience : the official journal of the Society for Neuroscience19.10(1999):3781-90.Details. Full text
  • BF O'Hara; E Macdonald; D Clegg; SW Wiler; R Andretic; VH Cao; JD Miller; HC Heller; TS Kilduff"Developmental changes in nicotinic receptor mRNAs and responses to nicotine in the suprachiasmatic nucleus and other brain regions."Brain research. Molecular brain research66.1-2(1999):71-82.Details. Full text
  • TS Kilduff; C Vugrinic; SL Lee; JD Milbrandt; JD Mikkelsen; BF O'Hara; HC Heller"Characterization of the circadian system of NGFI-A and NGFI-A/NGFI-B deficient mice."Journal of biological rhythms13.4(1998):347-57.Details. Full text
  • BF O'Hara; DM Edgar; VH Cao; SW Wiler; HC Heller; TS Kilduff; JD Miller"Nicotine and nicotinic receptors in the circadian system."Psychoneuroendocrinology23.2(1998):161-73.Details. Full text
  • BF O'Hara; FL Watson; R Andretic; SW Wiler; KA Young; L Bitting; HC Heller; TS Kilduff"Daily variation of CNS gene expression in nocturnal vs. diurnal rodents and in the developing rat brain."Brain research. Molecular brain research48.1(1997):73-86.Details. Full text
  • SK Welch; BF O'Hara; TS Kilduff; HC Heller"Sequence and tissue distribution of a candidate G-coupled receptor cloned from rat hypothalamus."Biochemical and biophysical research communications209.2(1995):606-13.Details. Full text
  • BF O'Hara; R Andretic; HC Heller; DB Carter; TS Kilduff"GABAA, GABAC, and NMDA receptor subunit expression in the suprachiasmatic nucleus and other brain regions."Brain research. Molecular brain research28.2(1995):239-50.Details. Full text
  • DA Clegg; BF O'Hara; HC Heller; TS Kilduff"Nicotine administration differentially affects gene expression in the maternal and fetal circadian clock."Brain research. Developmental brain research84.1(1995):46-54.Details. Full text
  • BF O'Hara; DM Donovan; I Lindberg; MT Brannock; DD Ricker; CA Moffatt; BA Klaunberg; C Schindler; TS Chang; RJ Nelson"Proenkephalin transgenic mice: a short promoter confers high testis expression and reduced fertility."Molecular reproduction and development38.3(1994):275-84.Details. Full text
  • L Bitting; EL Sutin; FL Watson; LE Leard; BF O'Hara; HC Heller; TS Kilduff"C-fos mRNA increases in the ground squirrel suprachiasmatic nucleus during arousal from hibernation."Neuroscience letters165.1-2(1994):117-21.Details. Full text
  • P Gregor; BF O'Hara; X Yang; GR Uhl"Expression and novel subunit isoforms of glutamate receptor genes GluR5 and GluR6."Neuroreport4.12(1993):1343-6.Details.
  • AM Persico; BF O'Hara; S Farmer; R Gysin; SD Flanagan; GR Uhl"Dopamine D2 receptor gene Taq I 'A' locus map including 'A4' variant: relevance for alcoholism and drug abuse."Drug and alcohol dependence31.3(1993):229-34.Details. Full text
  • BF O'Hara; KA Young; FL Watson; HC Heller; TS Kilduff"Immediate early gene expression in brain during sleep deprivation: preliminary observations."Sleep16.1(1993):1-7.Details. Full text
  • P Gregor; RH Reeves; EW Jabs; X Yang; W Dackowski; JM Rochelle; Brown RH Jr; JL Haines; BF O'Hara; GR Uhl"Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans."Proceedings of the National Academy of Sciences of the United States of America90.7(1993):3053-7.Details. Full text
  • AM Persico; CW Schindler; BF O'Hara; MT Brannock; GR Uhl"Brain transcription factor expression: effects of acute and chronic amphetamine and injection stress."Brain research. Molecular brain research20.1-2(1993):91-100.Details. Full text
  • SS Smith; BF O'Hara; AM Persico; DA Gorelick; DB Newlin; D Vlahov; L Solomon; R Pickens; GR Uhl"Genetic vulnerability to drug abuse. The D2 dopamine receptor Taq I B1 restriction fragment length polymorphism appears more frequently in polysubstance abusers."Archives of general psychiatry49.9(1992):723-7.Details. Full text
  • DM Donovan; M Takemura; BF O'Hara; MT Brannock; GR Uhl"Preproenkephalin promoter "cassette" confers brain expression and synaptic regulation in transgenic mice."Proceedings of the National Academy of Sciences of the United States of America89.6(1992):2345-9.Details. Full text
  • GR Cutting; L Lu; BF O'Hara; LM Kasch; C Montrose-Rafizadeh; DM Donovan; S Shimada; SE Antonarakis; WB Guggino; GR Uhl"Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina."Proceedings of the National Academy of Sciences of the United States of America88.7(1991):2673-7.Details. Full text
  • RH Reeves; MR Crowley; BF O'Hara; JD Gearhart"Sex, strain, and species differences affect recombination across an evolutionarily conserved segment of mouse chromosome 16."Genomics8.1(1990):141-8.Details. Full text
  • BF O'Hara; S Fisher; ML Oster-Granite; JD Gearhart; RH Reeves"Developmental expression of the amyloid precursor protein, growth-associated protein 43, and somatostatin in normal and trisomy 16 mice."Brain research. Developmental brain research49.2(1989):300-4.Details. Full text
  • C Bendotti; GL Forloni; RA Morgan; BF O'Hara; ML Oster-Granite; RH Reeves; JD Gearhart; JT Coyle"Neuroanatomical localization and quantification of amyloid precursor protein mRNA by in situ hybridization in the brains of normal, aneuploid, and lesioned mice."Proceedings of the National Academy of Sciences of the United States of America85.10(1988):3628-32.Details. Full text
  • RH Reeves; BF O'Hara; WJ Pavan; JD Gearhart; O Haller"Genetic mapping of the Mx influenza virus resistance gene within the region of mouse chromosome 16 that is homologous to human chromosome 21."Journal of virology62.11(1988):4372-5.Details. Full text
  • BF O'Hara; C Bendotti; RH Reeves; ML Oster-Granite; JT Coyle; JD Gearhart"Genetic mapping and analysis of somatostatin expression in Snell dwarf mice."Brain research464.4(1988):283-92.Details.
  • BF O'Hara; SS Smith; G Bird; AM Persico; BK Suarez; GR Cutting; GR Uhl"Dopamine D2 receptor RFLPs, haplotypes and their association with substance use in black and Caucasian research volunteers."Human heredity43.4(1969):209-18.Details. Full text
  • EG Stopa; GR Uhl; BF O'Hara; RL Chorsky; JC King; ED Bird; H Wolfe"Somatostatin-gene expression in the postmortem adult and fetal human brain."Peptide research5.4(1969):201-5.Details.
  • T Hou; C Wang; S Joshi; BF O'Hara; MC Gong; Z Guo"Active Time-Restricted Feeding Improved Sleep-Wake Cycle in <i>db/db</i> Mice."Frontiers in neuroscience13.(0):969.Details. Full text
  • BF O'Hara; Mongrain V"Sleepy genes."Frontiers in neuroscience4.(0):183.Details. Full text
  • F Yaghouby; CJ Schildt; KD Donohue; BF O'Hara; S Sunderam"Validation of a closed-loop sensory stimulation technique for selective sleep restriction in mice."Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference2014.(0):3771-4.Details.
  • RK Rowe; M Striz; AD Bachstetter; LJ Van Eldik; KD Donohue; BF O'Hara; J Lifshitz"Diffuse brain injury induces acute post-traumatic sleep."PloS one9.1(0):e82507.Details. Full text
  • M Jan; BF O'Hara; P Franken"Recent advances in understanding the genetics of sleep."F1000Research9.(0):Details. Full text
  • RK Rowe; JL Harrison; BF O'Hara; J Lifshitz"Diffuse brain injury does not affect chronic sleep patterns in the mouse."Brain injury28.4(0):504-10.Details. Full text
  • SF Lichtenthaler; BF O'Hara; CP Blobel"iRhoms in the brain - a new frontier?"Cell cycle (Georgetown, Tex.)14.19(0):3003-4.Details. Full text
  • JA Kull; KL Proudfoot; GM Pighetti; JM Bewley; BF O'Hara; KD Donohue; PD Krawczel"Effects of acute lying and sleep deprivation on the behavior of lactating dairy cows."PloS one14.8(0):e0212823.Details. Full text
  • MJ Duncan; H Farlow; C Tirumalaraju; DH Yun; C Wang; JA Howard; MN Sanden; BF O'Hara; KJ McQuerry; AD Bachstetter"Effects of the dual orexin receptor antagonist DORA-22 on sleep in 5XFAD mice."Alzheimer's & dementia (New York, N. Y.)5.(0):70-80.Details.
  • RH Reeves; D Gallahan; BF O'Hara; R Callahan; JD Gearhart"Genetic mapping of Prm-1, Igl-1, Smst, Mtv-6, Sod-1, and Ets-2 and localization of the Down syndrome region on mouse chromosome 16."Cytogenetics and cell genetics44.2-3(0):76-81.Details.
* Publications are automatically pulled from pubmed.gov based on a user-specific query. Results may include incorrect citations. See: Tutorial on improving PubMed results.