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Stabilizing gene regulatory networks through feedforward loops.

Author
Abstract
:

The global dynamics of gene regulatory networks are known to show robustness to perturbations in the form of intrinsic and extrinsic noise, as well as mutations of individual genes. One molecular mechanism underlying this robustness has been identified as the action of so-called microRNAs that operate via feedforward loops. We present results of a computational study, using the modeling framework of stochastic Boolean networks, which explores the role that such network motifs play in stabilizing global dynamics. The paper introduces a new measure for the stability of stochastic networks. The results show that certain types of feedforward loops do indeed buffer the network against stochastic effects.

Year of Publication
:
2013
Journal
:
Chaos (Woodbury, N.Y.)
Volume
:
23
Issue
:
2
Number of Pages
:
025107
ISSN Number
:
1054-1500
URL
:
https://doi.org/10.1063/1.4808248
DOI
:
10.1063/1.4808248
Short Title
:
Chaos
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