Tramutola, A. ., Lanzillotta, C. ., Di Domenico, F. ., Head, E. ., Butterfield, D. ., Perluigi, M. ., & Barone, E. . (2020). Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome. Neurobiology of Disease, 137, 104772. https://doi.org/10.1016/j.nbd.2020.104772

Tramutola, A. ., Pupo, G. ., Di Domenico, F. ., Barone, E. ., Arena, A. ., Lanzillotta, C. ., … Perluigi, M. . Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic Phenotype. Journal of Alzheimer’s Disease : JAD, 52(1), 359-371. https://doi.org/10.3233/JAD-151105 (Original work published 2016)

Tramutola, A. ., Di Domenico, F. ., Barone, E. ., Perluigi, M. ., & Butterfield, D. . It Is All about (U)biquitin: Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer Disease. Oxidative Medicine and Cellular Longevity, 2016, 2756068. https://doi.org/10.1155/2016/2756068 (Original work published 2016)

Barone, E. ., Di Domenico, F. ., Cassano, T. ., Arena, A. ., Tramutola, A. ., Lavecchia, M. ., … Perluigi, M. . (2016). Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm. Free Radical Biology & Medicine, 91, 127-42. https://doi.org/10.1016/j.freeradbiomed.2015.12.012

Di Domenico, F. ., Tramutola, A. ., & Butterfield, D. . (2017). Role of 4-hydroxy-2-nonenal (HNE) in the pathogenesis of alzheimer disease and other selected age-related neurodegenerative disorders. Free Radical Biology & Medicine, 111, 253-261. https://doi.org/10.1016/j.freeradbiomed.2016.10.490

Tramutola, A. ., Arena, A. ., Cini, C. ., Butterfield, D. ., & Barone, E. . (2017). Modulation of GLP-1 signaling as a novel therapeutic approach in the treatment of Alzheimer’s disease pathology. Expert Review of Neurotherapeutics, 17(1), 59-75. https://doi.org/10.1080/14737175.2017.1246183

Tramutola, A. ., Di Domenico, F. ., Barone, E. ., Arena, A. ., Giorgi, A. ., di Francesco, L. ., … Perluigi, M. . (2017). Polyubiquitinylation Profile in Down Syndrome Brain Before and After the Development of Alzheimer Neuropathology. Antioxidants & Redox Signaling, 26(7), 280-298. https://doi.org/10.1089/ars.2016.6686 (Original work published 2017)

Perluigi, M. ., Picca, A. ., Montanari, E. ., Calvani, R. ., Marini, F. ., Matassa, R. ., … Barone, E. . (2022). Aberrant crosstalk between insulin signaling and mTOR in young Down syndrome individuals revealed by neuronal-derived extracellular vesicles. Alzheimer’s & Dementia : The Journal of the Alzheimer’s Association, 18(8), 1498-1510. https://doi.org/10.1002/alz.12499

Lanzillotta, C. ., Tramutola, A. ., Di Giacomo, G. ., Marini, F. ., Butterfield, D. ., Di Domenico, F. ., … Barone, E. . (2021). Insulin resistance, oxidative stress and mitochondrial defects in Ts65dn mice brain: A harmful synergistic path in down syndrome. Free Radical Biology & Medicine, 165, 152-170. https://doi.org/10.1016/j.freeradbiomed.2021.01.042

Perluigi, M. ., Tramutola, A. ., Pagnotta, S. ., Barone, E. ., & Butterfield, D. . (2020). The BACH1/Nrf2 Axis in Brain in Down Syndrome and Transition to Alzheimer Disease-Like Neuropathology and Dementia. Antioxidants (Basel, Switzerland), 9(9). https://doi.org/10.3390/antiox9090779 (Original work published 2020)