Glucocorticoids Modulate Th1 and Th2 Responses in Asthmatic Mouse Models by Inhibition of Notch1 Signaling.
| Author | |
|---|---|
| Abstract |
:
Notch1 has been linked to the pathogenesis of asthma due to its contribution on Th1/Th2 imbalance. γ-Secretase inhibitor (GSI) acts as an effective blocker of Notch1 signaling. Glucocorticoids (GCs) are the most effective anti-inflammatory drugs for asthma. The present study investigated the involvement of the Notch1 pathway in the anti-inflammatory effect of GCs and its association with Th1/Th2 balance. |
| Year of Publication |
:
2018
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| Journal |
:
International archives of allergy and immunology
|
| Date Published |
:
2018
|
| ISSN Number |
:
1018-2438
|
| URL |
:
https://www.karger.com?DOI=10.1159/000485890
|
| DOI |
:
10.1159/000485890
|
| Short Title |
:
Int Arch Allergy Immunol
|
| Download citation |
