Inhibitory alkaloids from Dictamnus dasycarpus root barks on lipopolysaccharide-induced nitric oxide production in BV2 cells.
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| Abstract |
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The methanolic extract of Dictamnus dasycarpus root barks afforded one new glycosidic quinoline alkaloid, 3-[1β-hydroxy-2-(β-D-glucopyranosyloxy)-ethyl)-4-methoxy-2(1H)-quinolinone (1), together with nine known compounds, preskimmianine (2), 8-methoxy-N-methylflindersine (3), dictamine (4), γ-fagarine (5), halopine (6), skimmianine (7), dictangustine-A (8), iso-γ-fagarine (9), isomaculosidine (10). The isolated alkaloids significantly inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 cells. Among them, compounds 3 and 7 showed the most potent inhibitory activities on LPS-induced NO production. |
| Year of Publication |
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1969
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| Journal |
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Journal of enzyme inhibition and medicinal chemistry
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| Date Published |
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2011 Aug 10
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| ISSN Number |
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1475-6366
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| URL |
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http://informahealthcare.com/doi/abs/10.3109/14756366.2011.598151
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| DOI |
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10.3109/14756366.2011.598151
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| Short Title |
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Inhibitory alkaloids from Dictamnus dasycarpus root barks on lip
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