AKAP18δ Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR.
| Author | |
|---|---|
| Abstract |
:
The sarcoplasmic reticulum (SR) Ca-ATPase 2 (SERCA2) mediates Ca reuptake into SR and thereby promotes cardiomyocyte relaxation, whereas the ryanodine receptor (RYR) mediates Ca release from SR and triggers contraction. Ca/CaMKII (CaM [calmodulin]-dependent protein kinase II) regulates activities of SERCA2 through phosphorylation of PLN (phospholamban) and RYR through direct phosphorylation. However, the mechanisms for CaMKIIδ anchoring to SERCA2-PLN and RYR and its regulation by local Ca signals remain elusive. The objective of this study was to investigate CaMKIIδ anchoring and regulation at SERCA2-PLN and RYR. |
| Year of Publication |
:
2022
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| Journal |
:
Circulation research
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| Volume |
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130
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| Issue |
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1
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| Number of Pages |
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27-44
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| Date Published |
:
2022
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| ISSN Number |
:
0009-7330
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| URL |
:
https://www.ahajournals.org/doi/abs/10.1161/CIRCRESAHA.120.317976?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
|
| DOI |
:
10.1161/CIRCRESAHA.120.317976
|
| Short Title |
:
Circ Res
|
| Download citation |
