Photoactive Ru(II) complexes with dioxinophenanthroline ligands are potent cytotoxic agents.
| Author | |
|---|---|
| Abstract |
:
Two novel strained ruthenium(II) polypyridyl complexes containing a 2,3-dihydro-1,4-dioxino[2,3-f]-1,10-phenanthroline (dop) ligand selectively ejected a methylated ligand when irradiated with >400 nm light. The best compound exhibited a 1880-fold increase in cytotoxicity in human cancer cells upon light-activation and was 19-fold more potent than the well-known chemotherapeutic, cisplatin. |
| Year of Publication |
:
2014
|
| Journal |
:
Inorganic chemistry
|
| Volume |
:
53
|
| Issue |
:
19
|
| Number of Pages |
:
10030-2
|
| Date Published |
:
2014
|
| ISSN Number |
:
0020-1669
|
| URL |
:
https://doi.org/10.1021/ic5017164
|
| DOI |
:
10.1021/ic5017164
|
| Short Title |
:
Inorg Chem
|
| Download citation |
