No Gut No Gain! Enteral Bile Acid Treatment Preserves Gut Growth but Not Parenteral Nutrition-Associated Liver Injury in a Novel Extensive Short Bowel Animal Model.
| Author | |
|---|---|
| Abstract |
:
Parenteral nutrition (PN) provides nutrition intravenously; however, this life-saving therapy is associated with significant liver disease. Recent evidence indicates improvement in PN-associated injury in animals with intact gut treated with enteral bile acid (BA), chenodeoxycholic acid (CDCA), and a gut farnesoid X receptor (FXR) agonist, which drives the gut-liver cross talk (GLCT). We hypothesized that similar improvement could be translated in animals with short bowel syndrome (SBS). |
| Year of Publication |
:
2018
|
| Journal |
:
JPEN. Journal of parenteral and enteral nutrition
|
| Volume |
:
42
|
| Issue |
:
8
|
| Number of Pages |
:
1238-1251
|
| ISSN Number |
:
0148-6071
|
| URL |
:
https://doi.org/10.1002/jpen.1167
|
| DOI |
:
10.1002/jpen.1167
|
| Short Title |
:
JPEN J Parenter Enteral Nutr
|
| Download citation |
