Decoupling the downstream effects of germline nuclear RNAi reveals that H3K9me3 is dispensable for heritable RNAi and the maintenance of endogenous siRNA-mediated transcriptional silencing in <i>Caenorhabditis elegans</i>.
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Abstract |
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Germline nuclear RNAi in is a transgenerational gene-silencing pathway that leads to H3K9 trimethylation (H3K9me3) and transcriptional silencing at the target genes. H3K9me3 induced by either exogenous double-stranded RNA (dsRNA) or endogenous siRNA (endo-siRNA) is highly specific to the target loci and transgenerationally heritable. Despite these features, the role of H3K9me3 in siRNA-mediated transcriptional silencing and inheritance of the silencing state at native target genes is unclear. In this study, we took combined genetic and whole-genome approaches to address this question. |
Year of Publication |
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0
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Journal |
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Epigenetics & chromatin
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Volume |
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10
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Number of Pages |
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6
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Date Published |
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2017
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URL |
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https://epigeneticsandchromatin.biomedcentral.com/articles/10.1186/s13072-017-0114-8
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DOI |
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10.1186/s13072-017-0114-8
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Short Title |
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Epigenetics Chromatin
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