Skip to main content

Decoupling the downstream effects of germline nuclear RNAi reveals that H3K9me3 is dispensable for heritable RNAi and the maintenance of endogenous siRNA-mediated transcriptional silencing in <i>Caenorhabditis elegans</i>.

Author
Abstract
:

Germline nuclear RNAi in is a transgenerational gene-silencing pathway that leads to H3K9 trimethylation (H3K9me3) and transcriptional silencing at the target genes. H3K9me3 induced by either exogenous double-stranded RNA (dsRNA) or endogenous siRNA (endo-siRNA) is highly specific to the target loci and transgenerationally heritable. Despite these features, the role of H3K9me3 in siRNA-mediated transcriptional silencing and inheritance of the silencing state at native target genes is unclear. In this study, we took combined genetic and whole-genome approaches to address this question.

Year of Publication
:
0
Journal
:
Epigenetics & chromatin
Volume
:
10
Number of Pages
:
6
Date Published
:
2017
URL
:
https://epigeneticsandchromatin.biomedcentral.com/articles/10.1186/s13072-017-0114-8
DOI
:
10.1186/s13072-017-0114-8
Short Title
:
Epigenetics Chromatin
Download citation