TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation.
| Author | |
|---|---|
| Abstract |
:
Diabetic retinopathy (DR) is induced by an accumulation of reactive metabolites such as ROS, RNS, and RCS species, which were reported to modulate the activity of cation channels of the TRPC family. In this study, we use Trpc1/4/5/6-/- compound knockout mice to analyze the contribution of these TRPC proteins to diabetic retinopathy. |
| Year of Publication |
:
2018
|
| Journal |
:
Molecular metabolism
|
| Date Published |
:
2018
|
| DOI |
:
10.1016/j.molmet.2018.01.003
|
| Short Title |
:
Mol Metab
|
| Download citation |
