Potent and selective pharmacodynamic synergy between the metabotropic glutamate receptor subtype 2-positive allosteric modulator JNJ-46356479 and levetiracetam in the mouse 6-Hz (44-mA) model.
| Author | |
|---|---|
| Abstract |
:
We previously demonstrated that positive allosteric modulators (PAMs) of metabotropic glutamate subtype 2 (mGlu2 ) receptors have potential synergistic interactions with the antiseizure drug levetiracetam (LEV). The present study utilizes isobolographic analysis to evaluate the combined administration of JNJ-46356479, a selective and potent mGlu2 PAM, with LEV as well as sodium valproate (VPA) and lamotrigine (LTG). |
| Year of Publication |
:
2018
|
| Journal |
:
Epilepsia
|
| Date Published |
:
2018
|
| ISSN Number |
:
0013-9580
|
| URL |
:
http://dx.doi.org/10.1111/epi.14005
|
| DOI |
:
10.1111/epi.14005
|
| Short Title |
:
Epilepsia
|
| Download citation |
