Cenini, G. ., Dowling, A. ., Beckett, T. ., Barone, E. ., Mancuso, C. ., Murphy, M. ., … Head, E. . (2012). Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome. Biochimica Et Biophysica Acta, 1822(2), 130-8. https://doi.org/10.1016/j.bbadis.2011.10.001
E Head
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Head
Lanzillotta, C. ., Zuliani, I. ., Tramutola, A. ., Barone, E. ., Blarzino, C. ., , … Di Domenico, F. . (2021). Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention. Progress in Neurobiology, 196, 101892. https://doi.org/10.1016/j.pneurobio.2020.101892
Tramutola, A. ., Lanzillotta, C. ., Di Domenico, F. ., Head, E. ., Butterfield, D. ., Perluigi, M. ., & Barone, E. . (2020). Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome. Neurobiology of Disease, 137, 104772. https://doi.org/10.1016/j.nbd.2020.104772
Tramutola, A. ., Di Domenico, F. ., Barone, E. ., Arena, A. ., Giorgi, A. ., di Francesco, L. ., … Perluigi, M. . (2017). Polyubiquitinylation Profile in Down Syndrome Brain Before and After the Development of Alzheimer Neuropathology. Antioxidants & Redox Signaling, 26(7), 280-298. https://doi.org/10.1089/ars.2016.6686 (Original work published 2017)
Tramutola, A. ., Pupo, G. ., Di Domenico, F. ., Barone, E. ., Arena, A. ., Lanzillotta, C. ., … Perluigi, M. . Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic Phenotype. Journal of Alzheimer’s Disease : JAD, 52(1), 359-371. https://doi.org/10.3233/JAD-151105 (Original work published 2016)
Barone, E. ., Head, E. ., Butterfield, D. ., & Perluigi, M. . (2017). HNE-modified proteins in Down syndrome: Involvement in development of Alzheimer disease neuropathology. Free Radical Biology & Medicine, 111, 262-269. https://doi.org/10.1016/j.freeradbiomed.2016.10.508
Barone, E. ., Arena, A. ., Head, E. ., Butterfield, D. ., & Perluigi, M. . (2018). Disturbance of redox homeostasis in Down Syndrome: Role of iron dysmetabolism. Free Radical Biology & Medicine, 114, 84-93. https://doi.org/10.1016/j.freeradbiomed.2017.07.009
Di Domenico, F. ., Tramutola, A. ., Foppoli, C. ., Head, E. ., Perluigi, M. ., & Butterfield, D. . (2018). mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia. Free Radical Biology & Medicine, 114, 94-101. https://doi.org/10.1016/j.freeradbiomed.2017.08.009
Opii, W. ., Joshi, G. ., Head, E. ., Milgram, N. ., Muggenburg, B. ., Klein, J. ., … Butterfield, D. . (2008). Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer’s disease. Neurobiology of Aging, 29(1), 51-70. https://doi.org/10.1016/j.neurobiolaging.2006.09.012
Barone, E. ., Mancuso, C. ., Di Domenico, F. ., Sultana, R. ., Murphy, M. ., Head, E. ., & Butterfield, D. . (2012). Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease. Journal of Neurochemistry, 120(1), 135-46. https://doi.org/10.1111/j.1471-4159.2011.07538.x